We found MDD-related metabolic and network dysfunction at baseline. Improvement in depressive
symptoms was greater in patients receiving creatine augmentation relative to placebo augmentation. After 8 weeks
of treatment, prefrontal N-acetylaspartate levels increased significantly in the creatine augmentation group compared
with the placebo augmentation group. Increment in rich club hub connections was also greater in the creatine
augmentation group than in the placebo augmentation group.