The possibility that therapy might be effective specifically in women who are deficient in these vitamins was
not supported by the World Health Organization study (ISRCTN86677348) of vitamin C and E supplementation, which showed that supplementation with these vitamins, as compared with placebo, did not reduce the risk of preeclampsia in
a high-risk and nutritionally deficient population (relative risk with vitamins, 1.0; 95% CI, 0.9 to 1.3)