The effects of these redox-active species on cells,tissues,and bacteria are believed to be responsible for most CAP-related effects. It is important to note that in biology, living cells and tissues are always wet or located in a liquid environment ;thus ,in contrast to dry plasma application on surfaces e.g. in sterilization—CAP interacts first with the liquid,which in turn mediates CAP-induced effects. For more details,we recommend are view by Jablonowski and von Woedtke [7].
Since many diseases and pathological conditions,such as impaired wound healing and microcirculation,are related to restricted (NO) bioavailability,exogenous (NO) application also by cold plasma treatment may represent a novel therapeuti coption [8,9].
Considering the striking similarities between the biological results obtained by CAP or (NO) treatment,it seems obvious that (NO) should play a crucial rele in CAP-induced effects.
Therefore,in this mini review we will give a short introduction to (NO) physiology, as well as an overview of the literature concerning (NO)-based treatments and CAP sources,with a focus on
decontamination, and skin and wound healing.