(1) Anti-Proliferative and anti-migratory activity: Berberine is capable of inhibiting growth and
endogenous platelet-derived growth factor synthesis in vascular smooth muscle cells after in vitro
mechanical injury. A study, analyzed the effects of berberine on vascular smooth muscle cell
growth, migration, and signaling events after exogenous platelet-derived growth factor
stimulation in vitro in order to mimic a post-angioplasty platelet-derived growth factor shedding
condition.