. Acute and chronic GVHD were
diagnosed and graded according to previously established
criteria. Tosufloxacin and fluconazole were orally administered
14 days before allo-HSCT for prophylaxis against bacterial
and fungal infection, respectively. For patients with a
high risk of invasive fungal infections, voriconazole was
administered instead of fluconazole. Trimethoprim and sulfamethoxazole
were administered to prevent Pneumocystis
pneumonia. Acyclovir was administered to prevent herpes
simplex virus infection until the end of administration of
immunosuppressive drugs. Cytomegalovirus (CMV) disease
monitoring using an antigenemia assay for pre-emptive ganciclovir
therapy was performed.