Unfortunately, not all studies show an improvement of psychia ric
symptoms following parathyroidectomy. Bollerslev, et al., conducted
a prospective study of 191 individuals with PHPT randomized into
medical observation or PTX. Researchers used both the SF-36 and
the Comprehensive Psychopathological Rating Scale (CPRS) to
compare the two groups of patients between 1-2 years after surgery.
Asymptomatic PHPT patients demonstrated lower Quality of Life (QOL) scores on the SF-36 when compared to controls at baseline.
Two years following PTX, the authors found no clear improvement
on either questionnaire [31]. Amstrup, et al., conducted a cross-
sectional study of 51 PHPT patients compared to population-based,
age matched controls and found that patients reported consistently
worse QOL scores (using the SF-36) 5 years after PTX [32]. Table
1 summarizes the major studies looking at the effects of PTX on
psychiatric symptoms.