A DNEL (long term – oral route – general population)
of 2.1 mg/kg bw/d was proposed for S (IUCLID, 2013). The
calculation of DNELs is based on toxicity benchmarks, usually the
No/Low Observed Adverse Effect Levels (NOAEL/LOAEL) found in
experimental animals or epidemiological studies and the application
of assessment factors (AFs).