The effect of three amoxycillin treatment regimens on purulent secretions of patients with
bronchiectasis has been studied. On the basis of information recorded on a diary card the patients
were divided into three groups, according to the usual nature of their secretions: seven who produced
mucoid sputum, which occasionally became purulent; seven whose secretions were usually
mucopurulent but occasionally purulent; and 19 whose secretions were persistently purulent.
Treatment with capsules of amoxycillin in a dosage of 250 mg three times a day resulted in clearance
of purulent secretions in patients of the mucoid group when they were treated for a clinical
exacerbation. The sputum remained clear in these patients for long periods before a further
exacerbation (median 6 l/2, range 1- 11 months).