We performed a proteomic study to understand how Saccharomyces cerevisiae adapts its metabolism during
the exponential growth on three different concentrations of glucose; this information will be necessary to
understand yeast carbon metabolism in different environments. We induced a natural diauxic shift by
growing yeast cells in glucose restriction thus having a fast and complete glucose exhaustion. We noticed
differential expressions of groups of proteins. Cells in high glucose have a decreased growth rate during the
initial phase of fermentation; in glucose restriction and in high glucose we found an over-expression of a
protein (Peroxiredoxin) involved in protection against oxidative stress insult. The information obtained in
our study validates the application of a proteomic approach for the identification of the molecular bases of
environmental variations such as fermentation in high glucose and during a naturally induced diauxic shift.