Instrumentation
Chromatographic separation was performed on an ACQUITYTM Ultra Performance Liquid Chromatography system (Waters, Mil-ford, MA, USA), consisting of a binary solvent delivery system andan autosampler. MS/MS detection was performed on a Xevo®TQtandem quadrupole mass spectrometer (Waters, USA) equippedwith an electrospray ionization (ESI) source. Data were acquiredand processed with MassLynx V4.1 software.