The World Health Organization defines health as “a state of
complete physical, mental and social well-being and not
merely the absence of disease or infirmity.” It is necessary
then to examine not only the biologic effects of treatments/
interventions, but also the ramifications with regard to an
individual’s quality of life. Patient reported outcomes—
including the subjective measure of health related quality of
life (HRQL)—have been used for more than 40 years and offer
an additional layer of consideration for clinicians/
researchers.13 There are many instruments that have been
developed to quantify HRQL for both generic and diseasespecific
purposes.14 Generic tools can be used in a wide
range of populations and are often adapted/translated for
different language and cultural settings. Conversely, specific
tools tend to have content-focused approaches to quality of
life and will examine, for example, the effects of one condition
(ie, cardiovascular disease). Because vitamin D has
widespread roles throughout the body and is associated with
many chronic diseases and mental health, it is important to
know/understand whether vitamin D supplementation has
any effects on HRQL. The objectives of this systematic review
were to assess the effect of vitamin D supplementation on
quality-of-life outcomes in both healthy and clinical populations
and assess the process/methodologic quality of these
reported investigations.
The World Health Organization defines health as “a state ofcomplete physical, mental and social well-being and notmerely the absence of disease or infirmity.” It is necessarythen to examine not only the biologic effects of treatments/interventions, but also the ramifications with regard to anindividual’s quality of life. Patient reported outcomes—including the subjective measure of health related quality oflife (HRQL)—have been used for more than 40 years and offeran additional layer of consideration for clinicians/researchers.13 There are many instruments that have beendeveloped to quantify HRQL for both generic and diseasespecificpurposes.14 Generic tools can be used in a widerange of populations and are often adapted/translated fordifferent language and cultural settings. Conversely, specifictools tend to have content-focused approaches to quality oflife and will examine, for example, the effects of one condition(ie, cardiovascular disease). Because vitamin D haswidespread roles throughout the body and is associated withmany chronic diseases and mental health, it is important toknow/understand whether vitamin D supplementation hasany effects on HRQL. The objectives of this systematic reviewwere to assess the effect of vitamin D supplementation onquality-of-life outcomes in both healthy and clinical populationsand assess the process/methodologic quality of thesereported investigations.
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