In summary, the present study indicates that ABGE treatment inhibits growth of SGC-7901 cells by inducing apoptosis in vitro. More importantly, we present the first evidence that ABGE is an effective anticancer garlic preparation in a mouse model. The beneficial effects of ABGE may be partly due to its antioxidative and immunomodulatory activities. Due to its broad range of beneficial effects, serious assessment of ABGE in clinical trials is warranted for the prevention and treatment of gastric cancer.