In a recent paper published in PLOS ONE, Torres-Perez and colleagues investigated the neurobiological effects of the natural flavonoid found in grapes Resveratrol (RVTL) on hippocampal neuroplasticity and cognitive performance in rodents using a wide range of techniques (Torres-Perez et al., 2015). Although several reports have already highlighted a neuroprotective effect of RVTL (Sonmez et al., 2007; Vingtdeux et al., 2010), its neuroprotective mechanisms have remained elusive. As such, Torres-Perez and coauthors decided to explore the complex beneficial effects of RVTL on the hippocampus, a key brain region involved in aging as well as in learning and memory functions.