The fact that the patient was a
chronic smoker and used e-cigarettes to quit smoking, may have
contributed to the rapid metabolism of nicotine, the biotransformation
of which depends also on nicotine addiction. In case No. 1,
nicotine concentrations in the analyzed serum samples were more
than twice higher than in persons smoking for long periods of time,
in which after 30 min of 6.5-h smoking, the recorded nicotine
concentrations in the blood ranged from 0.012 to 0.044 mg/L
[23]. Cotinine concentrations in the patient serum discussed were
significantly higher