In this multicenter randomized trial
involving neonates $28 weeks’ gestational
age undergoing planned noninvasive
respiratory support, we found
no significant difference between
HHHFNC and nCPAP with regard to the
primary outcome of intubation within
the initial 72 hours of support. In addition,
we found no differences between
infants randomly assigned to
nCPAP compared with HHHFNC for
several respiratory outcomes, including
duration of oxygen supplementation,
diagnosis of BPD, or discharge from
the hospital on oxygen.