ABSTRACT: The antidepressant effects of Ziziphora tenuior L. (Z. tenuior) hydroalcoholic extract in animal models of depression was investigated. The effect of extract (50, 75 and 100 mg/kg) on immobility, swimming and climbing behaviours were evaluated in forced swim test (FST) and tail suspension test (TST). Imipramine (30mg/kg) and fluoxetine (20mg/kg) were used as a reference drugs. Results showed that different doses of extract significantly reduced immobility time in FST (p