RESULTS AND DISCUSSION
We first examined whether emulsifiers affected SG skin penetration when applied in an O/W-type emulsion. O/W-type
emulsions were prepared using 6 emulsifiers that are commonly used in cosmetics (an anionic ion surfactant SSG; nonionic surfactants SMS, PO80, PMS, and HCO; and an amphoteric ion surfactant HSL). The particle size of each emulsion was approximately 200 nm, and each emulsion showed good stability
Figure 2 shows the amount of SG that penetrated the YMP skin. With HCO, SSG, and PMS, SG exhibited high levels of skin penetration. However, there was no significant difference between all formulations; the type of surfactant had little influence on SG skin penetration. The amount of SG that penetrated into the dermis was less than 1% for all emulsions,
and most of the SG was detected in both the epidermis and the stratum corneum.
Next, we examined whether SG applied in the oil phase affected skin penetration by using the 3 types of LP with HCO as an emulsifier (Table 1). Figure 3 shows the amounts of SG that penetrated the skin from 3 different O/W emulsions containing different types of liquid paraffin (LP-A, LP-B, and LP-C). The amount of SG skin penetration differed significantly between them (LP-A>LP-B>LP-C). The water contained in the O/W emulsion evaporated on the skin, and the oil phase remained on the skin surface after phase inversion. Therefore, we also examined the skin penetration of the oil phase of the O/W emulsion, and compared the emulsion with the oil phase. SG penetration into the skin was enhanced approximately 1.5-fold with the O/W emulsion, compared to the oil phase. We observed a significant difference between
the O/W emulsion and the oil phase (Fig. 3).
To clarify and visualize skin penetration, we used DiI, which has a molecular weight of 834 Da and a log P of 23.2. Figure 4 shows CLSM images of cross-sections of YMP skin after exposure to O/W emulsions. DiI penetration into the stratum corneum differed significantly, with LP-A>LP-C (Fig. 4). This phenomenon was also evident with regard to SG.
RESULTS AND DISCUSSION
We first examined whether emulsifiers affected SG skin penetration when applied in an O/W-type emulsion. O/W-type
emulsions were prepared using 6 emulsifiers that are commonly used in cosmetics (an anionic ion surfactant SSG; nonionic surfactants SMS, PO80, PMS, and HCO; and an amphoteric ion surfactant HSL). The particle size of each emulsion was approximately 200 nm, and each emulsion showed good stability
Figure 2 shows the amount of SG that penetrated the YMP skin. With HCO, SSG, and PMS, SG exhibited high levels of skin penetration. However, there was no significant difference between all formulations; the type of surfactant had little influence on SG skin penetration. The amount of SG that penetrated into the dermis was less than 1% for all emulsions,
and most of the SG was detected in both the epidermis and the stratum corneum.
Next, we examined whether SG applied in the oil phase affected skin penetration by using the 3 types of LP with HCO as an emulsifier (Table 1). Figure 3 shows the amounts of SG that penetrated the skin from 3 different O/W emulsions containing different types of liquid paraffin (LP-A, LP-B, and LP-C). The amount of SG skin penetration differed significantly between them (LP-A>LP-B>LP-C). The water contained in the O/W emulsion evaporated on the skin, and the oil phase remained on the skin surface after phase inversion. Therefore, we also examined the skin penetration of the oil phase of the O/W emulsion, and compared the emulsion with the oil phase. SG penetration into the skin was enhanced approximately 1.5-fold with the O/W emulsion, compared to the oil phase. We observed a significant difference between
the O/W emulsion and the oil phase (Fig. 3).
To clarify and visualize skin penetration, we used DiI, which has a molecular weight of 834 Da and a log P of 23.2. Figure 4 shows CLSM images of cross-sections of YMP skin after exposure to O/W emulsions. DiI penetration into the stratum corneum differed significantly, with LP-A>LP-C (Fig. 4). This phenomenon was also evident with regard to SG.
การแปล กรุณารอสักครู่..
