Here, suppression of emotion-expressive behavior, associated with reduced negative emotion experience and behavior, was associated with activity within bilateral dorsomedial PFC (MdPFC), right dorsolateral PFC (DLPFC) and left ventrolateral PFC (VLPFC). Greater, rather than reduced, bilateral subcortical limbic (that is, amygdala, insula) activity accompanied voluntary suppression, however, suggesting that although suppression may constitute an emotion regulation strategy, it may not be the most beneficial as a therapeutic strategy