Garcinia mangostana is a medicinal plant has been used for hundreds of years in
Southeast Asia as a medicine for treatment of various medical conditions. Thus, the
study planned to biosynthesize silver nanoparticles using aqueous fruit extract of
Garcinia mangostana (G. mangostana) and to evaluate their antibacterial and
antioxidant activity in vitro. The synthesized silver nanoparticles (AgNPs) were
confirmed by color transformation and Ultraviolet-visible (UV-visible)
spectrophotometry. The appearance of dark brown color and UV absorption spectra
range at 430nm confirmed the synthesized silver nanoparticles. The Transmission
Electron Microscope (TEM) analysis showed that the sizes of the synthesized
AgNPs ranged from 30 to 50nm. These biologically synthesized AgNPs were
tested for antibacterial activity against three human pathogens such as Escherchia
coli, Pseudomonas auroginosa, and staphylococcus aureus. The obtained
nanoparticles showed significant inhibitory activity on all bacterial species. The
free radical scavenging activity was assessed by DPPH (1, 1-Diphenyl-2-
picrylhydrazyl) assay. The biosynthesized AgNPs showed significantly higher
antioxidant activity compared to G. mangostana fruit extract alone. It could be
concluded that the synthesis of silver nanoparticles using aqueous fruit extract of
G. mangostana helpful for the preparation of pharmacologically useful drugs.