Discussion.
To our knowledge, this pilot study is the first human trial to address the effects of Spirulina supplementation on liver function and health-related quality of life in patients with NAFLD. Our study yielded outcomes that showed beneficial effects of Spirulina supplementation within observed parameters on 15 NAFLD Cretan outpatients, including a significant reduction in serum liver enzymes and lipids, and additionally an improvement in scores on health-related quality of life.