Present investigation was carried out to study of spontaneous occurrence of various pathological conditions in the livers of buffaloes, with possible correlation to haematological parameters. Examination of livers and blood from a total number of 510 buffaloes ranging from 4 to12 years of age were examined for liver affections and haematological alterations. The material was collected from Cantonment Board Slaughter House, Mhow (M.P). The mean values of packed cell volume (PCV), haemoglobin (Hb), and mean corpuscular volume and total plasma protein in all pathological conditions of the livers were higher than normal whereas in differential leucocytes count (DLC), lymphocytosis was revealed during the different pathological conditions of liver, except in case of suppurative hepatitis, hyaline degeneration and cloudy swelling in which the lymphocytes were within the normal range.