It was hypothesized that proteins fibrillation is an oxidation-triggered process and may be inhibited by antioxidant agents that suppress the generation of reactive oxygen species. Whey protein-originated fibrils may be exploited in formation of heat-resistant protein-stabilized emulsions and nanoemulsions. However, more effort is required to characterize the interfacial behavior of fibrils in comparison with native and heat-denatured whey proteins. Gastric and intestinal digestion fate of protein nanofibrils is also a hot topic for upcoming research studies.