Six spirostanol glycosides (1–6) and 12 known compounds (7–18) were isolated from the underground
parts of Dracaena thalioides (Agavaceae). Their structures were determined by spectroscopic analysis,
including 2D NMR spectroscopic data, and chemical transformations. The isolated compounds were evaluated
for cytotoxic activity against HL-60 human leukemia cells. Compounds 1, 3–6, and 8–18 showed
cytotoxicity against HL-60 cells, of which 10, a bisdesmosidic spirostanol derivative, showed potent cytotoxicity
against HL-60 cells with an IC50 value of 0.38 lM and induced apoptosis in HL-60 cells.
Six spirostanol glycosides (1–6) and 12 known compounds (7–18) were isolated from the undergroundparts of Dracaena thalioides (Agavaceae). Their structures were determined by spectroscopic analysis,including 2D NMR spectroscopic data, and chemical transformations. The isolated compounds were evaluatedfor cytotoxic activity against HL-60 human leukemia cells. Compounds 1, 3–6, and 8–18 showedcytotoxicity against HL-60 cells, of which 10, a bisdesmosidic spirostanol derivative, showed potent cytotoxicityagainst HL-60 cells with an IC50 value of 0.38 lM and induced apoptosis in HL-60 cells.
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