A consistent definition for neonatal hypoglycemia in the first 48 h of life continues to elude us. Enhanced
understanding of metabolic disturbances and genetic disorders that underlie alterations in postnatal
glucose homeostasis has added useful information to understanding transitional hypoglycemia. This
growth in knowledge still has not led to what we need to know: “How low is too low and for how long?”
This article reviews the current state of understanding of neonatal hypoglycemia and how different
approaches reach different “expert” opinions.