. Clustered Regularly Interspaced Short Palindromic Repeats (CRISPRs) are bacterial immune defense mechanisms against invading viruses. Bacteria are able to integrate short portions of the viral DNA into specific genomic areas in the bacterial genome that are later on used for the production of specific small RNAs targeting viral genomes during subsequent infections. A recent paper showed the simultaneous disruption of five different genes in the mouse genome using the CRISPR/Cas system (Wang et al., 2013). Moreover, in 80% of cases, biallelic mutations in several genes have been identified. Although no transgenic plants have been yet produced using this system, the scientific community will see them very soon.