From a mechanistic point of view, while a published
computational model [13] suggested an explanation for
the potential role of the Ile655Val SNP in carcinogenesis,
the Ala1170Pro SNP has not been evaluated for its
potential biologic function so far. However, the position
of the latter variant within the carboxyl-terminal tail,
which is the main substrate of activation-dependent
tyrosine phosphorylation and subsequent recruitment
of adaptor proteins, could suggest a phosphorylation
regulatory function.