The 15 boys fulfilling the inclusion criteria were started on
70 μg rhGH/kg·d (=0.49 mg/kg·wk). Titration of rhGH dose was adjusted
every 3 months to growth velocity and maintenance of IGF-1
level between 0.5 and 1.5 SDS, as previously reported [32], a compromise
between the two IGF-1 titrating regimens proposed by Cohen
et al. [8,10,11]. If the growth velocity was b1.5 cm/3 months, the rhGH
dose was increased by 20% while maintaining serum IGF-1 below +1
SD. Treatment was stopped when the growth velocity stood below
5 mm in 3 months or when the adolescent has reached a height
N169 cm. Patients were seen between 17.5 and 18.5 years for adult
height measurement