In rat percutaneous studies with the cream formulation, the peaks of radioactivity in
most tissues were achieved at 12 hours. The largest amounts of radioactivity were
found in the liver and adrenals, however, the concentration started to decrease after 24
hours. The patterns of tissue distribution and elimination of radioactivity were similar
after the single and multiple applications, suggesting that any significant retention of
drug and or its metabolites in the tissues was unlikely.