MDR A. baumannii has turned into one of the maincauses of hospital-acquired infection. MDR A. baumannii frequently produces hospital-acquired infection and endemic situations in intensive care units (ICUs) all over the world [3,4]. P. aeruginosa has a similar trajectory.
Ventilator-associated pneumonia (VAP) is one of the most common and severe hospital-acquired infections. The most common etiologies of VAP are GNB, and among them MDR-GNB are very frequently isolated. VAP is associated with increased attributable mortality, length of stay and use of resources in the ICU [5]. In addition, the risk of inappropriate
empiric antimicrobial treatment is higher in areas with a high prevalence of MDR-GNB. The inappropriate empiric treatment of VAP is a risk factor for a poorer prognosis
[6-8]. It has been suggested that combined treatment could help improve the results of VAP, since it broadens the antibacterial spectrum [9]. This hypothesis has not been
confirmed in a clinical trial that compared meropenem plus ciprofloxacin with meropenem in monotherapy [10]. Inmany ICUs the proportion of resistance to all the betalactams
(including carbapenems) and quinolones is so high (over 30 to 50%) [11,12] that empirical treatment with these antimicrobials, even if combined, results in inappropriate
treatment in a high percentage of cases
MDR A. baumannii has turned into one of the maincauses of hospital-acquired infection. MDR A. baumannii frequently produces hospital-acquired infection and endemic situations in intensive care units (ICUs) all over the world [3,4]. P. aeruginosa has a similar trajectory.Ventilator-associated pneumonia (VAP) is one of the most common and severe hospital-acquired infections. The most common etiologies of VAP are GNB, and among them MDR-GNB are very frequently isolated. VAP is associated with increased attributable mortality, length of stay and use of resources in the ICU [5]. In addition, the risk of inappropriateempiric antimicrobial treatment is higher in areas with a high prevalence of MDR-GNB. The inappropriate empiric treatment of VAP is a risk factor for a poorer prognosis[6-8]. It has been suggested that combined treatment could help improve the results of VAP, since it broadens the antibacterial spectrum [9]. This hypothesis has not beenconfirmed in a clinical trial that compared meropenem plus ciprofloxacin with meropenem in monotherapy [10]. Inmany ICUs the proportion of resistance to all the betalactams(including carbapenems) and quinolones is so high (over 30 to 50%) [11,12] that empirical treatment with these antimicrobials, even if combined, results in inappropriatetreatment in a high percentage of cases
การแปล กรุณารอสักครู่..
