Our result showed that aloe vera did not delay the onset of severe mucositis when compared with the placebo. Patients who received aloe vera developed less mucositis with statistically significant difference from the placebo group. Our findings also confirmed using logistic regression analysis, that there was a significant association between aloe vera treatment and lower mucositis grading. Our results showed that aloe vera could only reduced the incidence of severe mucositis but could not delay the onset of severe mucositis. We suggested that the discordant outcome might mean that the aloe vera effect is not strong enough for mucositis prevention but adequate for alleviating and slowing down the progression of mucositis