Recently, in another study, it was found that there
are specific polyphenol receptor sites in the skin that bind resveratrol,
which then exert protective effects against the nitric oxide
free radical donor sodium nitroprusside (SNP). To determine
the receptor binding, the authors treated human skin tissue sections
with [3H]-resveratrol followed by studying localization of signals.
A significant binding of resveratrol was seen in the epidermis,
with some binding in the dermis. The study also determined that
the resveratrol binding site was also present in vitro, in HaCaT cells,
an immortalized human keratinocyte cell line [68]. This study
gives promise to the notion that skin diseases and cancers can be
treated with resveratrol because of the resveratrol-specific binding
sites in the skin