qualitative inquiry revealed multiple challenges in the provision of care, yet professionalism prevailed. Nurses expressed negative attitudes in challenges in with patients with substance abuse/dependence care i of safety, fear, manipulation, and specifically and need for education. Consistent with the existing literature, findings support the need for enhanced educational provisions to nurses, both in basic educational preparation and continuing educational offerings, as well as the development and/or enhancement of supportive collegial networks in the practice setting.