Sunlight: Ultraviolet rays in sunlight cause collagen to break down at an increased rate, damaging collagen fibers and inducing the accumulation of abnormal elastin. Abnormal elastin leads to the production of an enzyme that can also break down collagen. This process can lead to the formation of solar scars.24
Autoimmune disorders: Some autoimmune disorders cause antibodies to target collagen. Mutations to the genes responsible for the coding of collagen alpha-chains can affect the extracellular matrix, leading to a decrease in the amount of collagen secreted, or to the secretion of dysfunctional mutant collagen.1
Collagen levels deplete naturally over time and there is no way to prevent this intrinsic aging. However, by taking precautionary measures, it is possible to reduce extrinsic aging and protect collagen, keeping the skin, bones, muscles and joints healthy for longer.