White blood cells (WBC) or leukocytes play a significant role in the diagnosis of different diseases (including Leukemia), and therefore, extracting information about that isvaluable for hematologists. Leukemia refers to a progressive,malignant disease of the blood-forming organs. Complete blood count process is the first step for leukemia screening [4].The pathology is characterized by the uncontrolled accumulation of immature white blood cells. The four main types of leukemia are Acute Myelogenous Leukemia (AML); Acute Lymphoblastic Leukemia (ALL); Chronic Myeloid Leukemia (CML); Chronic Lymphocytic Leukemia (CLL). In this paper, we build up a decision support tool to improve classification of Acute Myelogenous Leukemia (AML). AML is a fast-growing cancer of the blood and bone marrow.