Preharvest and postharvest Fusarium infection of cereals, especially of wheat and barley, cause huge losses in grain crop production and additionally lead to toxicologically relevant accumulation of Fusarium mycotoxins in the grains. The most prevalent mycotoxin is the trichothecene deoxynivalenol. A major effect of trichothecenes on eukaryotic cells is inhibition of protein synthesis. Additionally, an inhibition of RNA and DNA synthesis, as well as adverse effects on mitochondrial functionwere also described. Repetitive exposure to trichothecenes results in injury to actively dividing cells, such as those present in bone marrow, intestinal mucosa, spleen, and thymus. Following ingestion of contaminated feed, the intestinal epithelium can be exposed to high concentrations of DON. Consequently, the digestive tract is a primary target to elicit toxic effects. As the gastrointestinal tract is vital for adequate nutrient supply, it is of importance to characterize the effect of DON on nutrient absorption in animals. Previously, the feeding of purified DON to broilers has been shown to affect small intestinal morphology at levels below those that cause adverse effects on performance. The results of that study indicated that the feeding of purified DON at 10 mg/kg of feed to broilers for 6 weeks resulted in shorter and thinner villi in the duodenum and jejunum. Body weight gain and efficiency of feed utilization, however, were not affected by the consumption of DON indicating the high compensatory capacity of the digestive tract. Glucose is a key fuel and an important metabolic substrate in