Background: Chronic rhinosinusitis with eosinophilic infiltration
(ECRS) has been noted a severe and intractable type of
rhinosinusitis, which is often associated with asthma.
Macrophages as well as eosinophilic infiltration have been
reported to take part in the processes of severe asthma. Mucus
hypersecretion and persistent airway inflammation results from
the increased expression of mucin gene (MUC5AC). Oxidants
are well known to induce the characteristic features that
aggravate asthma. Superoxide dismutase (SOD), a
cytoprotective enzyme against oxidants, has been extensively
studied in airway diseases. From the viewpoint of “One way
one disease”, we examined whether SOD could be associated
with infiltrating macrophages, MUC5AC and other factors that
exacerbate the rhinosinusitis.