Patients with COPD have a cough that is frequently associated with chronic sputum production (74). Characteristically, these individuals present with dyspnea and effort limitations due to the fixed airflow obstruction (75)-(77). More advanced stages of the disease result in a worse quality of life for these patients. Respiratory exacerbations are associated with an increased underlying inflammatory process that requires appropriate therapy with antibiotics and systemic corticosteroids. These exacerbations are characterized by a worsening of the basal symptoms of the patient, such as cough, expectoration and dyspnea. According to the Global Initiative for Chronic Obstructive Lung Disease (GOLD), an exacerbation is defined as “an event in the natural course of the disease characterized by a change in dyspnea, cough and/or basal expectoration of the patient who goes beyond the normal daily variation, and that can cause a change in regular medication of the patient