Downregulation of the expression of specific genes
through RNA interference (RNAi), has been widely used
for genetic research in insects. The method has relied on
the injection of double-stranded RNA (dsRNA), which is
not possible for practical applications in crop protection.
By contrast, specific suppression of gene expression in
nematodes is possible through feeding with dsRNA. This
approach was thought to be unfeasible in insects, but
recent results have shown that dsRNA fed as a diet
component can be effective in downregulating targeted
genes. More significantly, expression of dsRNA directed
against suitable insect target genes in transgenic plants
has been shown to give protection against pests, opening
the way for a new generation of insect-resistant
crops.