In year 2003, Matsumoto et al. studied on the effect of xanthones isolated
from mangosteen fruit pericarp on the cell growth inhibition of human
leukemia cell line HL60. Matsumoto et al. reported that α-mangostin
(Figure 2.20) has cytotoxicity on leukemia cell lines, for example K562,
NB4 and U937. Additionally, α-mangostin was also investigated in the
short-term chemopreventive effects on putative preneoplastic lesions
involved in rat colon carcinogenesis (Nabandith et al., 2004).