Oseltamivir is the antiviral most frequently used to treated
transplant patients, although the optimal dose and duration
of therapy is still incompletely understood Just as in hospitalized adults, nearly all data
about oseltamivir in immunocompromised patients come
from retrospective studies Although
early antiviral therapy (typically with oseltamivir) is associated
with clinical benefit, therapy initiated beyond 48 h
after symptom onset is probably beneficial and, because of
prolonged viral shedding, therapy beyond 5 days may be
required A prospective study is ongoing to hopefully
address the optimal dose and duration of therapy