We found that key indicators of neighborhood social disorganization were significantly related to the acquisition of trichomoniasis among a sample of young adults, above and beyond individual and neighborhood control variables. Specifically, we found that young adults who lived in neighborhoods with a higher concentration of Black residents were more likely to have trichomoniasis compared with those who lived in neighborhoods with lower concentrations of Black residents. However, concentrated poverty mediated this relationship, and, once adjusted, the relationship between neighborhood concentration of Black residents and trichomoniasis was not significant.