The aim of the present study was to explore stress (symptoms of depression and anxiety), coping and the overall quality of life of orphaned children in comparison to non-orphans who resided with their parents.We sampled 200 participants aged between 7 and 17 years, with 100 being orphaned children placed in four orphanages (experimental group) and 100 non-orphans from two public schools in Accra, Ghana (control group). The participants completed the Children's Depression Inventory, the Revised Children'sManifest Anxiety Scale, the Kidcope scale and the World Health Organization Quality of Life-BREF Version. One-way Analysis of Variance revealed that orphaned children showed more anxiety symptoms than non-orphans but there were no significant differences between orphaned children and non-orphans on symptoms of depression and overall quality of life. The Pearson product-moment correlation analyses revealed significant correlations regression analyses also revealed that for orphaned children, anxiety and support-seeking coping emerged as
significant predictors of qualify of life whereas depression emerged as a significant predictor of quality of life
for the non-orphaned children. The implications of the results are discussed