It is well known that the liver plays an important role in homeostasis and the overall metab-olism of animals. While a robust and rapid initiation of the host defense mechanism is essential for a successful parasite clearance during the early cyst established phase, on the other hand, an excessive immune defense can produce temporary or permanent damage of the host, as sug-gested by the up-regulation of genes associated with liver injury (PIK42B, GPR155 and FAIM2) in the present study. Therefore, a restriction of a thriving innate immune response is necessary to limit host defense[38].