A Cochrane meta-analysis of twelve
randomized and controlled trials revealed that nifedipine,
the most commonly used calcium antagonist, is
superior to betamimetics with respect to the prolongation
of pregnancy by seven days and past the 34th
week of gestation (22). The administration of nifedipine
lowers the frequency of neonatal intraventricular
hemorrhage (OR 0.53, 95% CI 0.34–0.84), respi -
ratory distress syndrome (OR 0.63, 95% CI
0.46–0.86), and necrotizing enterocolitis (OR 0.21,
95% CI 0.05–0.94) (23). Its side effects, including
nausea, flushing, headache, palpitations, and (often)
reflex tachycardia, are less severe than those of betamimetics
(18).
A Cochrane meta-analysis of twelverandomized and controlled trials revealed that nifedipine,the most commonly used calcium antagonist, issuperior to betamimetics with respect to the prolongationof pregnancy by seven days and past the 34thweek of gestation (22). The administration of nifedipinelowers the frequency of neonatal intraventricularhemorrhage (OR 0.53, 95% CI 0.34–0.84), respi -ratory distress syndrome (OR 0.63, 95% CI0.46–0.86), and necrotizing enterocolitis (OR 0.21,95% CI 0.05–0.94) (23). Its side effects, includingnausea, flushing, headache, palpitations, and (often)reflex tachycardia, are less severe than those of betamimetics(18).
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