Glyphosate is the most produced and utilized herbicide in the world. The classification by the IARC as a “probable carcinogen” is challenging it’s increasing use on GM crops in Brazil. The country has made a Resolution from the Board of Collegiate (RDC) in 2008, which determined the toxicological revaluation of the technical and formulation products of glyphosate and other pesticides was necessary. The review finally requested the necessity to establish the ADI by registrants and control the impurities present in the technical material and other potential adverse toxicological effects