The signaling pathways resulting in plant resistance induced by F. oxysporum are still largely unknown. The findings of a few studies led to the hypothesis that some protective strains of F. oxysporum prime plant defense reactions. It would be interesting to use different strains of F. oxysporum to determine whether priming is a mechanism common to all strains or specific to some protective strains. It will then be necessary to analyse the signaling pathways using plant mutants defective in the SA, ET or JA pathway. In this field of research, most of the data available in the literature concern A. thaliana.However, we must question the use of A. thaliana for the study of plant–F. oxysporum interactions. Indeed, there is no report of a specific forma specialis infecting A. thaliana and strains used to study A. thaliana–F. oxysporum interactions belong to different formaespeciales attacking Brassicae or even tomato.