The endogenous functions of Y. lipolytica have been manipulated
for biosynthesis of various bioproducts. This created a plethora of
yeast products, as reviewed in the literature (Barth and Gaillardin,
1996). Generally, Y. lipolytica strains can be used to produce fuels
and chemicals whose microbial productions require the carbon
flux to be directed to the FA synthesis pathway. Together with
GRAS status and intrinsic capability for high-level production of
large heterologous proteins, this makes the engineered Y. lipolytica
platform quite attractive for use in the production of various FAbased
biofuel and bioproducts. For instance, using Y. lipolytica to
produce a variety of lipid-derived compounds such as wax ester,
isoprenoid-derived compounds, polyhydroxyalkanoates (PHA),
and free hydroxylated FAs from lipid substrate has been investigated
in European project, called “lipoYeasts” (Sabirova et al.,
2011).
The next subsections focus on FA-based bioproducts that are
derived or produced from the engineered lipid pathways in this
yeast. These bioproducts are briefly presented in Figure 2.
The endogenous functions of Y. lipolytica have been manipulatedfor biosynthesis of various bioproducts. This created a plethora ofyeast products, as reviewed in the literature (Barth and Gaillardin,1996). Generally, Y. lipolytica strains can be used to produce fuelsand chemicals whose microbial productions require the carbonflux to be directed to the FA synthesis pathway. Together withGRAS status and intrinsic capability for high-level production oflarge heterologous proteins, this makes the engineered Y. lipolyticaplatform quite attractive for use in the production of various FAbasedbiofuel and bioproducts. For instance, using Y. lipolytica toproduce a variety of lipid-derived compounds such as wax ester,isoprenoid-derived compounds, polyhydroxyalkanoates (PHA),and free hydroxylated FAs from lipid substrate has been investigatedin European project, called “lipoYeasts” (Sabirova et al.,2011).The next subsections focus on FA-based bioproducts that arederived or produced from the engineered lipid pathways in thisyeast. These bioproducts are briefly presented in Figure 2.
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