secretion of various pro-inflammatory cytokines and chemokines they contribute to the development and propagation of radiation-induced inflammatory reaction [95].
CCL2 secreted by the activated macrophages is sensed by Treg cells through their CCR2 receptors and are directly attracted to the site of inflammation.
Thus, these data prove that Tregs can accumulate at inflammatory sites induced by ionizing radiation and, as shown above, can influence the level of DNA damage and repair through TGFβ production in responder cells.