Most of the patients evaluated in clinical
trials had hematologic malignancies or were undergoing HSCT,
although one recent randomized controlled trial demonstrated a
decreased rate of infection in patients with solid tumors undergoing
chemotherapy. Nonetheless, controversy exists regarding its use
in patients with solid tumors because of concerns about antibiotic
resistance.14,15,25–30 The benefi t of antibiotic prophylaxis if patients are
receiving CSFs requires further study.31
Herpes viral prophylaxis (acyclovir or vala