Glucosamine has been shown to reduce production of melanin in melanocyte cell culture [1]. The reported mechanism is inhibition of maturation of tyrosinase, specifically inhibiting the glycosylation of pro-tyrosinase to active tyrosinase. Clinical pigmentation effects of topical glucosamine have not been reported. We have investigated the effectiveness of a stable derivative of glucosamine, N-acetyl glucosamine (NAG), alone and in combination with a previously demonstrated effective material, niacinamide (N) [2], for clinically reducing the appearance of facial hyperpigmented spots.